US Patent Issued to CELLECTIS on March 17 for "Use of pre T alpha or functional variant thereof for expanding TCR alpha deficient T cells" (French, American Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,581, issued on March 17, was assigned to CELLECTIS (Paris).

"Use of pre T alpha or functional variant thereof for expanding TCR alpha deficient T cells" was invented by Roman Galetto (Paris), Agnes Gouble (Paris), Stephanie Grosse (Saint-cyr sur Morin, France), Cecile Mannioui (Villiers sur Marne, France), Laurent Poirot (Paris), Andrew Scharenberg (Seattle) and Julianne Smith (Le Plessis-Robinson, France).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of expanding TCRalpha deficient T-cells by expressing pTalpha or functional variants thereof into said cells, thereby restoring a functional CD3 complex. This method is particularly useful to...