US Patent Issued to BROADEN BIOSCIENCE AND TECHNOLOGY on July 21 for "Chimeric antigen receptor with modified hinge region and uses thereof" (Chinese, American Inventors)

ALEXANDRIA, Va., July 21 -- United States Patent no. 12,685,750, issued on July 21, was assigned to BROADEN BIOSCIENCE AND TECHNOLOGY CORP (Katy, Texas).

"Chimeric antigen receptor with modified hinge region and uses thereof" was invented by Buo Chen (Katy, Texas), Xiangqun Li (Beijing) and Ang Zhang (Beijing).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge domain, wherein the hinge domain comprises the amino acid sequence of SEQ ID NO:1. Cells expressing a CAR comprising the modified hinge domain disclosed herein are shown to have enhanced anti-tumor activities with reduced release of pro-inflammatory cytoki...