US Patent Issued to Board of Trustees of Michigan State University on Sept. 22 for "Pluripotent stem cell-derived heart organoid" (Michigan Inventors)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,742,157, issued on Sept. 22, was assigned to Board of Trustees of Michigan State University (East Lansing, Mich.).

"Pluripotent stem cell-derived heart organoid" was invented by Aitor Aguirre (Okemos, Mich.) and Yonatan Raz Israeli (Okemos, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for generating a heart organoid is provided. The method includes forming a cellular aggregate of pluripotent stem cells, activating Wnt signaling in the cellular aggregate to cause the cellular aggregate to differentiate into a three-dimensional cardiac mesoderm, and inhibiting the Wnt signaling in the cardiac mesoderm to form the heart organoid. The hear...