US Patent Issued to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM on June 9 for "High affinity engineered T-cell receptors targeting cmv infected cells" (Texas, Colorado Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,772, issued on June 9, was assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas).

"High affinity engineered T-cell receptors targeting cmv infected cells" was invented by Jennifer A. Maynard (Austin, Texas), Ellen Wagner (Larkspur, Colo.), Ahlam N. Qerqez (Cedar Park, Texas) and Annalee Nguyen (Austin, Texas).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are engineered T-celi receptors (TCRs) having nanomoiar affinity for the immuno-dominant pp65 peptide residing between residues 495-503 (NLV) in complex with HLA-A2*02:01. The TCRs may be membrane-hound TCRs, soluble TCRs, chimeric TCRs, or chimeric antigen rece...