ALEXANDRIA, Va., July 21 -- United States Patent no. 12,685,756, issued on July 21, was assigned to BIOVIE INC. (Reno, Nev.).

"Methods of treating disease with Terlipressin" was invented by Penelope Markham (Clifton, Va.) and Joseph M. Palumbo (Saint Davids, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are methods of treating a disease with arginine vasopressin or an analogue thereof that reduce the risk of hyponatremia. Specifically, the invention relates to the novel observation that subjects receiving co-administration of terlipressin and gabapentin or pregabalin have a high incidence of severe hyponatremia. The methods of the invention include either excluding subjects receiving gabapentin...