US Patent Issued to BIOTHEUS on April 14 for "Anti-PD-L1 and PD-L2 antibody and derivatives and use thereof" (Chinese Inventors)

ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,782, issued on April 14, was assigned to BIOTHEUS INC. (Zhuhai, China).

"Anti-PD-L1 and PD-L2 antibody and derivatives and use thereof" was invented by Xiaoniu Miao (Zhuhai, China), Fan Wu (Zhuhai, China) and Cheng Chen (Zhuhai, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "A PD-L1 nano-antibody and a PD-L2 nano-antibody, and a bispecific antibody having both the PD-L1 nano-antibody and the PD-L2 nano-antibody are disclosed. The bispecific antibody can block PD-1/PD-L1 and PD-1/PD-L2 pathways at the same time. The bispecific antibody can reactivate T cells, enhance immune responses, and more effectively improve the inhibitory effect on tumor...