ALEXANDRIA, Va., April 21 -- United States Patent no. 12,606,594, issued on April 21, was assigned to BicycleTx Ltd. (Cambridge, Great Britain).
"Heterotandem bicyclic peptide complexes" was invented by Gemma Mudd (Cambridge, Great Britain), Punit Upadhyaya (Lexington, Mass.), Kevin McDonnell (Lexington, Mass.) and Johanna Lahdenranta (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a heterotandem bicyclic peptide complex which comprises a first peptide ligand, which binds to EphA2, conjugated via a linker to two second peptide ligands, which bind to CD137. The invention also relates to the use of said heterotandem bicyclic peptide complex in preventing, suppr...