US Patent Issued to BeOne Medicines I on March 24 for "Pyrido[2,3-b[1,4oxazines or tetrahydropyrido[2,3-b[1,4oxazepines as IAP antagonists" (Chinese Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,866, issued on March 24, was assigned to BeOne Medicines I GmbH (Basel, Switzerland).

"Pyrido[2,3-b[1,4oxazines or tetrahydropyrido[2,3-b[1,4oxazepines as IAP antagonists" was invented by Jing Li (Beijing), Fengtao Song (Beijing) and Zhiwei Wang (Beijing).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the us...