US Patent Issued to BeiGene on March 24 for "Stable solid dispersion of a B-RAF kinase dimer inhibitor, methods of preparation, and uses therefor" (Chinese, American Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,604, issued on March 24, was assigned to BeiGene Ltd. (Grand Cayman, Cayman Islands).

"Stable solid dispersion of a B-RAF kinase dimer inhibitor, methods of preparation, and uses therefor" was invented by Guoliang Zhang (Beijing), Changyou Zhou (Princeton, N.J.) and Huangbin Sun (Beijing).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein is a physically stable solid dispersion comprising Compound 1, i.e., the B-RAF kinase dimer inhibitor 1-((1S, 1aS, 6bS)-5-((7-oxo-5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa [b] benzofuran-1-yl)-3-(2, 4, 5-trifluorophenyl) urea and a specific stabilizing polymer, the m...