US Patent Issued to Becton Dickinson and Co. on July 14 for "Polymerase chain reaction normalization through primer titration" (California Inventors)

ALEXANDRIA, Va., July 14 -- United States Patent no. 12,680,123, issued on July 14, was assigned to Becton Dickinson and Co. (Franklin Lakes, N.J.).

"Polymerase chain reaction normalization through primer titration" was invented by Katherine Lazaruk (San Jose, Calif.), Eleen Shum (San Jose, Calif.) and Christina Chang (San Jose, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein include systems, methods, compositions, and kits for PCR normalization. In some embodiments, after barcoding copies of a higher abundance target (e.g., a cDNA species), the barcoded copies are amplified using a pair of forward primers comprising one or more mismatches and a reverse primer. The amplified copies can...