US Patent Issued to Baylor College of Medicine on Sept. 29 for "Chagas disease vaccine antigens with improved stability and decreased aggregation" (American, Mexican Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,746,280, issued on Sept. 29, was assigned to Baylor College of Medicine (Houston).

"Chagas disease vaccine antigens with improved stability and decreased aggregation" was invented by Bin Zhan (Houston), Peter Jay Hotez (Houston), Maria Elena Botazzi (Houston) and Jaime Ortega-Lopez (Cuidad de Mexico, Mexico).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions and methods for the prevention and treatment of Chagas disease and acute and chronic symptoms thereof. The compositions comprise recombinant proteins based on an amino terminal fragment of the TSA-1 protein from Trypanosoma cruzi. In the fragment, one or more Cys residue...