US Patent Issued to Baylor College of Medicine on Feb. 10 for "Small-molecule modulators of the orphan nuclear receptor TLX" (Texas Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,657, issued on Feb. 10, was assigned to Baylor College of Medicine (Houston).

"Small-molecule modulators of the orphan nuclear receptor TLX" was invented by Damian Winston Young (Houston), Mirjana Maletic-Savatic (Houston), Prasanna Kandel (Houston), Fatih Semerci (Houston) and Srinivas Chamakuri (Houston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Small molecules acting through the ligand binding domain of nuclear receptor TLX (NR2E1) are disclosed, as well as the use thereof for promoting neurogenesis and treating disorders associated with nuclear receptor TLX, including neurological disorders such as Alzheimer's disease. In certain embodiments...