ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,703,741, issued on Aug. 11, was assigned to AVEO Pharmaceuticals Inc. (Boston).

"Treatment of congestive heart failure and other cardiac dysfunction using a GDF15 modulator" was invented by Jeno Gyuris (Lincoln, Mass.) and Lorena Lerner (Newton Centre, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides methods and compositions of treating a subject having a cardiac-related disorder such as congestive or chronic heart failure (CHF), cardiac hypertrophy, cardiac hypotrophy, and other cardiac myopathies/dystrophies. The methods comprise administering an effective amount of a composition that modulates, for example, reduces or inhib...