US Patent Issued to Augusta University Research Institute on June 30 for "Chimeric antigen receptor T cells and methods of use thereof" (Georgia Inventor)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,668,777, issued on June 30, was assigned to Augusta University Research Institute Inc. (Augusta, Ga.).

"Chimeric antigen receptor T cells and methods of use thereof" was invented by Gang Zhou (Martinez, Ga.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are engineered polyfunctional CD4+ T cells/CAR T cells and methods of their use for the treatment of cancers. One embodiment provides a method of producing polyfunctional CD4+ T cells by constitutively activating STAT5A in the cells to induce a polyfunctional phenotype. Also provided is a method of reversing exhaustion in tumor-specific CD4+ T cells by engineering the cells to express Fo...