US Patent Issued to Arvinas Operations on March 17 for "MDM2-based modulators of proteolysis and associated methods of use" (Connecticut, New Jersey Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,255, issued on March 17, was assigned to Arvinas Operations Inc. (New Haven, Conn.).

"MDM2-based modulators of proteolysis and associated methods of use" was invented by Andrew P. Crew (Chester, Conn.), Craig M. Crews (New Haven, Conn.), Hanqing Dong (Madison, Conn.), Yimin Qian (Plainsboro, N.J.) and Jing Wang (Milford, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibite...