US Patent Issued to ARVINAS OPERATIONS on Feb. 24 for "Tau-protein targeting compounds and associated methods of use" (Connecticut, New Jersey Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,486, issued on Feb. 24, was assigned to ARVINAS OPERATIONS INC. (New Haven, Conn.).

"Tau-protein targeting compounds and associated methods of use" was invented by Andrew P. Crew (Guilford, Conn.), Michael Berlin (Flemington, N.J.), Angela M. Cacace (Haddam Neck, Conn.) and Julian T. Chandler (Old Lyme, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moi...