US Patent Issued to Amgen on Dec. 23 for "Control of total afucosylated glycoforms of antibodies produced in cell culture" (California Inventors)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,503,700, issued on Dec. 23, was assigned to Amgen Inc. (Thousand Oaks, Calif.).

"Control of total afucosylated glycoforms of antibodies produced in cell culture" was invented by Chung-Jr Huang (Newbury Park, Calif.), Prince Bhebe (Moorpark, Calif.), Madiha Khurshid (Thousand Oaks, Calif.) and Li Zhang (Camarillo, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods of modulating the levels of total afucosylated (TAF) glycoforms of a recombinant glycosylated protein produced by glycosylation-competent cells in a cell culture. In exemplary embodiments, the methods comprise maintaining the cell culture at an initial set point p...