US Patent Issued to Altius Institute for Biomedical Sciences on June 23 for "DNA binding proteins for displacing endogenous transcription factors bound to gene regulatory regions" (Washington Inventors)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,662,516, issued on June 23, was assigned to Altius Institute for Biomedical Sciences (Seattle).

"DNA binding proteins for displacing endogenous transcription factors bound to gene regulatory regions" was invented by Jennifer M. Cherone (Seattle), Alister PW Funnell (Seattle) and John A. Stamatoyannopoulos (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods and compositions for modulating expression of a target gene in a cell by reducing binding of an endogenous transcription factor to a regulatory sequence of the target gene. The method includes introducing into the cell a DNA binding polypeptide (DBF) that bi...