US Patent Issued to Akebia Therapeutics on Oct. 6 for "PHD inhibitor compounds, compositions, and use" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,161, issued on Oct. 6, was assigned to Akebia Therapeutics Inc. (Cambridge, Mass.).

"PHD inhibitor compounds, compositions, and use" was invented by Paul E. Fleming (Cambridge, Mass.), Thomas P. Blaisdell (Cambridge, Mass.) and Senkara Rao Allu (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and val...