ALEXANDRIA, Va., June 16 -- United States Patent no. 12,653,852, issued on June 16, was assigned to Akamis Bio Inc. (Cambridge, Mass.).
"Oncolytic adenoviruses armed with heterologous genes" was invented by Brian Robert Champion (Oxfordshire, Great Britain), Alice Claire Noel Brown (Oxfordshire, Great Britain), Kerry David Fisher (Oxfordshire, Great Britain) and Tamara Nicolson (Oxfordshire, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR wherein: B1 is a bond or comprises: E1A, E1B or E1A-E1B; BA comprises: E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond...