ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,495, issued on Feb. 24, was assigned to Agency for Science, Technology and Research (Singapore).
"Purine diones as Wnt pathway modulators" was invented by Soo Yei Ho (Singapore), Stephanie Eliane Blanchard (Singapore), Athisayamani Jeyaraj Duraiswamy (Singapore), Jenefer Alam (Singapore) and Vikrant Arun Adsool (Singapore).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathwaywherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (oth...