US Patent Issued to ADAMA MAKHTESHIM on June 16 for "Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrimidin-2-one" (Israeli Inventors)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,655,109, issued on June 16, was assigned to ADAMA MAKHTESHIM LTD. (Beer Sheva, Israel).

"Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrimidin-2-one" was invented by Samaa Alasibi (Hura, Israel), Gal Suez (Dimona, Israel) and Eynat Matzner (Adi, Israel).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a process for preparing the compound 5-fluoro-4-imine-3-methyl-1-(phenyl-4-sulfonyl)-3,4-dihydro-1H-pyrimidin-2-one having the formula (I): comprising (a) reacting 5-fluorocytosine with compound having the formula (III): in the presence of at least one polar solvent and at least one base...