ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,237, issued on March 17, was assigned to ADAMA AGAN LTD. (Israel).
"Process and intermediates for the preparation of pyroxasulfone" was invented by Carl Recsei (Tel Aviv-Jaffa, Israel) and Yaniv Barda (Rehovot, Israel).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene br...