ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,496,281, issued on Dec. 16, was assigned to ABREXA PHARMACEUTICALS INC. (San Diego).

"Compounds for prevention and treatment of hemorrhage and vasculature instability" was invented by Jesus E. Villafranca (San Diego), Charles Richard Kissinger (San Diego) and Guohong Li (Hummelstown, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Hemorrhage and vascular instability can be induced by thrombolytic and anti-coagulant therapies. Presented herein, in certain aspects, are methods for the treatment and/or prevention of hemorrhage and vascular instability that comprise administering a compound disclosed herein to a subject in need thereof."

The patent was ...