US Patent Issued to ABCLONAL SCIENCE on May 19 for "TEV protease with dual affinity tags" (Massachusetts Inventors)

ALEXANDRIA, Va., May 19 -- United States Patent no. 12,630,813, issued on May 19, was assigned to ABCLONAL SCIENCE INC. (Woburn, Mass.).

"TEV protease with dual affinity tags" was invented by Dapeng Sun (Lexington, Mass.), Zhenyu Zhu (Lynnfield, Mass.) and Aine Quimby (Newburyport, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed is using a TEV protease (wild type or mutant) suited for removal from a reaction mixture, wherein the TEV protease displays a dual affinity tag including a chitin binding domain (CBD) tag and a histidine tag, preferably where the CBD tag precedes the N-terminus of the protease and the CBD tag is preceded by the histidine tag, which is preferably a 6-mer histidine tag; ...