US Patent Issued to AB Studio on April 21 for "Heteromultimeric proteins and methods of use thereof" (California Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,606,622, issued on April 21, was assigned to AB Studio Inc. (Hayward, Calif.).

"Heteromultimeric proteins and methods of use thereof" was invented by Yue Liu (Foster City, Calif.), Jianbo Dong (Santa Clara, Calif.) and Bo Wang (San Carlos, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides heteromultimeric proteins, such as bispecific antibodies, comprising a first antibody heavy chain constant domain 3 (CH3)-containing polypeptide having a substitution relative to a wildtype CH3 domain at amino acid position 354 with a bulky hydrophobic amino acid, and/or a second CH3-containing polypeptide comprising a substitution...