US Patent Issued on Oct. 27 for "Chondroitinase ABC mutants and methods of manufacture and use thereof" (Canadian, American Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,460, issued on Oct. 27.

"Chondroitinase ABC mutants and methods of manufacture and use thereof" was invented by Molly S. Shoichet (Toronto), Marian H. Hettiaratchi (Toronto), Teresa R. O'Meara (Summerland, Calif.) and Matthew J. O'Meara (Summerland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides a Chondroitinase ABC (ChABC) mutants. ChABC stimulates axonal regeneration by degrading the inhibitory chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans in the glial scar that forms after traumatic injuries to the central nervous system (CNS). However, the therapeutic utility of this potent, fragile prot...