ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,440,453, issued on Oct. 14.
"Intraarterial (IA) application of low dose of ethyl alcohol enables blood-brain barrier (BBB) impermeable therapeutics brain entry" was invented by Weijun Wang (Cypress, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method of inducing blood-brain barrier (BBB) opening of for delivery of a non-BBB permeable substance to a subject includes the steps of: administering an ethyl alcohol at 0.015%-5% v/v into a blood stream of the subject via intra-arterial injection, intracardiac injection, or intra-arterial injection guided by ultrasound, wherein said ethyl alcohol reaches a brain of the subject to induce opening of bl...