ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,781,274, issued on Nov. 3.
"Replicase cycling reaction (RCR) and the related RdRP-binding site designs thereof" was invented by Shi-Lung Lin (Arcadia, Calif.) and Sam Lin (Arcadia, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "This invention relates to a novel composition of RNA/mRNA medicines and/or vaccines produced by using Replicase/RNA-dependent RNA polymerase (RdRP)-mediated RNA Cycling Reaction (RCR). This RCR-amplifiable RNA/mRNA composition comprises at least a replicase/RdRP-binding site (RdRP-BS) in the 5'-end or 3'-end, or both, of a desired RNA sequence of interest, to form a self-amplifying RNA/mRNA (samRNA) platform. The samRNA pla...