ALEXANDRIA, Va., June 12 -- United States Patent no. 12,295,977, issued on May 13.
"Oncolytic reovirus" was invented by Maya Shmulevitz (Edmonton, Canada), Adil Mohamed (Edmonton, Canada), Mary Hitt (Edmonton, Canada) and Wan Kong Yip (Edmonton, Canada).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides modified reovirus with improved characteristics, including improved oncolytic activity. Reoviruses provided herein include resortant viruses as well as viruses expressing mutated proteins. Methods of using such modified reovirus for inducing cancer cell lysis as well as treatment of cancer are disclosed. Also provided are methods tailored for induction of a desired cytokine profile ...