ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,100, issued on March 31.

"Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the NRF2-Beta-TrCP interaction for use in the treatment of fatty liver disease" was invented by Antonio Cuadrado Pastor (Madrid), Raquel Fernandez Gines (Madrid), Jose Antonio Encinar (Elche, Spain), Rafael Leon Martinez (Madrid), Juan Felipe Franco Gonzalez (Madrid), Manuela Garcia Lopez (Madrid), Maria Isabel Rodriguez Franco (Madrid) and Ana Isabel Rojo Sanchis (Madrid).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to NRF2-BetaTrCP interaction inhibitors with general formula I and its derivate salts for use in the treatment of NR...