ALEXANDRIA, Va., July 28 -- United States Patent no. 12,692,545, issued on July 28.

"Combined auxiliary diagnostic method, kit, system and use of point mutation and methylation of bladder cancer driver genes" was invented by Li Lu (Hunan, China), Genming Xu (Hunan, China) and Qian Zhao (Hunan, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are the method, kit, system and use for screening or detecting or assisting in the diagnosis of bladder cancer, which are able to simultaneously detect FGFR3, TERT, PLEKHS1 point mutations and OTX1, NID2 and NRN1 methylation levels, thereby realizing the combined detection of gene point mutation and methylation, reducing the demand for samples, experimental...