International Clinical Trial: Efficacy and safety of intraventricular pemetrexed via Ommaya reservoir combined with systemic therapy for leptomeningeal metastases from lung adenocarcinoma

Geneva, Aug. 6 -- International Clinical Trials Registry received information related to the study (ChiCTR2600128649) titled 'Efficacy and safety of intraventricular pemetrexed via Ommaya reservoir combined with systemic therapy for leptomeningeal metastases from lung adenocarcinoma' on July 23.

Study Type: Interventional study

Study Design: Single arm

Primary Sponsor: Shanghai Pulmonary Hospital

Condition: leptomeningeal metastases from lung adenocarcinoma

Intervention: Ommaya reservoir treatment arm:Intracerebral injection of pemetrexed, 20-50 mg (dissolved in 5 ml of normal saline, based on the patient's body surface area and ECOG score), once every 3 weeks. The dose may be adjusted according to the patient's tolerance. Under s...