UNIVERSITY PARK, Pa., May 5 -- Pennsylvania State University issued the following news release:
UNIVERSITY PARK, Pa. - Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders, but some experience severe intellectual disability or developmental delay, while others may only exhibit milder psychiatric features like depression or anxiety. How can this be?
To answer this, a team led by Penn State scientists has developed methods to evaluate how genetic variants elsewhere in an individual's genome work with the deletion to help determine the features that the individual will manifest. Rather than the conventional focus on single causal variants for neurodevelopmental disorde...