Clinical Trial: VYVGART (Hytrulo) in Patients With Stiff Person Syndrome (SPS)

U.S., Oct. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07860021) titled 'VYVGART (Hytrulo) in Patients With Stiff Person Syndrome (SPS)' on Sept. 22.

Brief Summary: Stiff Person Syndrome (SPS) is a rare autoimmune disorder, characterized by: a) incapacitating diffuse muscle stiffness prominent in the axial, abdominal and thoracolumbar paraspinal muscles leading to hyperlordosis, difficulty turning and bending; b) painful muscle spasms precipitated by external stimuli with difficulty performing routine daily activities; and c) slow freezing gait with frequent falls and need for walking aids leading to disability. SPS is due to impaired inhibitory GABAergic neurotransmission associated with high-titer IgG a...