U.S., May 1 -- ClinicalTrials.gov registry received information related to the study (NCT07558798) titled 'Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart Failure' on April 07.
Brief Summary: This study evaluates whether natriuresis-guided diuretic therapy improves outcomes in patients with acute heart failure (AHF) and severe congestion. All patients hospitalized with AHF will be screened using Venous Excess Ultrasound (VExUS) and randomized 1:1 to either natriuresis-guided escalation of loop diuretics or standard care. The primary endpoint, evaluated in patients with VExUS grade 3 (severe congestion), is a hierarchical composite (win ratio) of 90-day mortality, 90-day rehospitalization, and hospital length of stay...