Clinical Trial: Tumoral Versus Luminal Microbiome in Head and Neck Squamous Cell Carcinoma

U.S., Sept. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07809100) titled 'Tumoral Versus Luminal Microbiome in Head and Neck Squamous Cell Carcinoma' on Aug. 28.

Brief Summary: Head and neck squamous cell carcinoma (HNSCC), France's 5th most common cancer (15,000 annual cases), presents significant public health challenges due to high morbidity and functional/aesthetic sequelae from treatments (mutilating surgery, radiotherapy, chemotherapy). Major risk factors, tobacco and alcohol, create a chronic inflammatory environment promoting tumor development. The upper aerodigestive tract microbiome, influenced by these exposures and local alterations (necrosis, bleeding, ulcerations), is emerging as a potentia...