U.S., April 22 -- ClinicalTrials.gov registry received information related to the study (NCT07543328) titled 'Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression' on April 14.
Brief Summary: The primary objective of this study is to evaluate the clinical efficacy of moderate-dose transcranial photobiomodulation (t-PBM) at different frequencies (10 Hz and 40 Hz) in patients with treatment-resistant depression (TRD). It further aims to explore the differential efficacy across various symptom subtypes, with a particular focus on the somatic symptom-dominant subtype. Additionally, this study will collect paired-pulse neurophysiological parameters (e.g., the ratio of cortical inhibition to excitation) t...