Clinical Trial: The Clinical Application Study of Obinutuzumab in Pediatric Refractory Nephrotic Syndrome

U.S., May 29 -- ClinicalTrials.gov registry received information related to the study (NCT07612592) titled 'The Clinical Application Study of Obinutuzumab in Pediatric Refractory Nephrotic Syndrome' on May 21.

Brief Summary: Primary nephrotic syndrome (PNS) in children is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia. The main subtypes include steroid-sensitive nephrotic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS), among which frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome (SDNS) are relatively common in clinical practice. In recent years, anti-CD20 monoclonal antibodies, such as rituximab (RTX), have achieved remarkable effi...