U.S., June 30 -- ClinicalTrials.gov registry received information related to the study (NCT07672899) titled 'Small RNA tRF-31 Changes in Patients With Age-Related Cataract' on June 23.
Brief Summary: The goal of this observational study is to evaluate the expression characteristics and clinical relevance of the tRF-31/HIPK2 signaling axis in adults over 18 years old with age-related cataract (ARC). The main questions it aims to answer are: Is there a correlation between the relative expression levels of tRF-31 and its target gene HIPK2 in the anterior lens capsule and the clinical severity (Emery-Little grading system) of age-related cataracts? Does oxidative stress in the anterior segment microenvironment have a potential bystander effect...