Clinical Trial: SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer

U.S., March 11 -- ClinicalTrials.gov registry received information related to the study (NCT07462663) titled 'SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer' on Nov. 23, 2025.

Brief Summary: SHAPE-ENDO is a prospective observational study conducted at Hospital Universitari de Bellvitge evaluating a multimodal pre-surgical optimization strategy for women with obesity (BMI >=35) and atypical endometrial hyperplasia or early-stage endometrial cancer. Participants receive standard-of-care interventions including semaglutide therapy, levonorgestrel intrauterine device (with or without oral progestins), structured nutrition and exercise programs, and scheduled endometrial surveillance...