U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07549399) titled 'SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC' on April 13.
Brief Summary: To explore the efficacy and safety of an intensified treatment regimen consisting of short-course radiotherapy followed by mFOLFOX6 chemotherapy combined with precise targeted therapy (based on RAS/BRAF status: cetuximab for wild-type, bevacizumab for mutant) and a PD-1 monoclonal antibody, compared with short-course radiotherapy followed by mFOLFOX6 chemotherapy alone, in high-risk locally advanced pMMR/MSS rectal adenocarcinoma through a prospective, randomized controlled phase III clinical study, providing high-level evidence-...