Clinical Trial: RSV Vaccination to Reduce Recurrent AECOPD

U.S., April 3 -- ClinicalTrials.gov registry received information related to the study (NCT07508644) titled 'RSV Vaccination to Reduce Recurrent AECOPD' on March 27.

Brief Summary: Objectives: To determine whether respiratory syncytial virus (RSV) vaccination reduces the rate of all-cause moderate-to-severe acute exacerbations of COPD (AECOPD) in high-risk patients, and to characterise RSV-specific infection and immune responses in this population.

Hypothesis: RSV vaccination in COPD frequent exacerbators receiving dual long-acting bronchodilators will reduce all-cause moderate-to-severe AECOPD by at least 20-25% over 12 months.

Design and subjects: This multicentre, two-arm, open-label, prospective study will recruit 320 COPD patients w...