Clinical Trial: RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling

U.S., Sept. 16 -- ClinicalTrials.gov registry received information related to the study (NCT07819643) titled 'RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling' on Sept. 06.

Brief Summary: Carotid artery stenosis is a major cause of ischemic stroke. However, many strokes occur in patients with only mild-to-moderate stenosis. Evidence shows that it is not the degree of narrowing, but the "vulnerability" of the plaque-its internal composition-that determines rupture risk.

High-risk (vulnerable) plaques have a large lipid-rich necrotic core, a thin fibrous cap, and intraplaque hemorrhage. Statins can lower cholesterol and stabilize plaques, but some patients still experience progression or recurrent events.

PCSK9 inhibitors ...