U.S., Oct. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07871123) titled 'Radiosurgery for Severe Refractory Cancer Pain: A Sham-Controlled Pilot Trial' on Oct. 07.
Brief Summary: This pilot randomized trial assessed whether a sham-controlled comparison of triple-target stereotactic radiosurgery is feasible in adults with advanced (stage IV) cancer and severe mixed pain refractory to optimized pharmacologic and specialist management. Participants were randomized 1:1 to single-session Gamma Knife radiosurgery delivered to the hypophysis and both medial thalami, or to an identical sham procedure without radiation; both arms continued standard pain care. The main comparison was the change in pain intensity o...