U.S., July 21 -- ClinicalTrials.gov registry received information related to the study (NCT07713745) titled 'Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)' on July 03.
Brief Summary: This is an adaptive platform-basket trial that aims to evaluate the safety and efficacy of multiple novel agents and combination therapies in patients with NF2-related schwannomatosis (NF2-SWN). The study employs a basket design to assess treatment responses across four tumor types commonly associated with NF2-SWN: vestibular schwannomas, non-vestibular schwannomas, meningiomas, and ependymomas.
A shared natural history observational cohort, receiving routine clinical follow-up without investigational treatment, serves as a common control ...