Clinical Trial: Pedi-STAR: Surface Target Antibody-drug Conjugate (ADC) Antigen Expression in Relapsed/Refractory Pediatric Solid and CNS Tumors

U.S., Sept. 1 -- ClinicalTrials.gov registry received information related to the study (NCT07793994) titled 'Pedi-STAR: Surface Target Antibody-drug Conjugate (ADC) Antigen Expression in Relapsed/Refractory Pediatric Solid and CNS Tumors' on Aug. 21.

Brief Summary: This study is looking to learn whether a tumor testing approach can feasibly measure antibody-drug conjugate (ADC) target proteins in children and young adults with relapsed or refractory solid tumors or central nervous system (CNS) tumors.

The tumor testing approach is a two-step tumor profiling process of:

* Screening with bulk RNA sequencing to see which ADC target genes are turned on in the tumor.

* Confirmatory immunohistochemistry (IHC) for targets that show positive ex...