Clinical Trial: Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

U.S., Oct. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07214207) titled 'Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking' on Oct. 01.

Brief Summary: The goal of this clinical trial is to learn if, how, and for whom suvorexant (SUV) works to treat alcohol use disorder (AUD). The main questions it aims to answer are:

* Is SUV effective for AUD?

* Does SUV dampen stress reactivity?

* Can the researchers develop a biomarker for SUV treatment response?

Researchers will compare SUV to a placebo (a look-alike substance that contains no drug) to see if drug SUV works to treat AUD.

Participants will:

* Take 10mg capsules of SUV or a placebo orally each night ...