Clinical Trial: Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)

U.S., May 30 -- ClinicalTrials.gov registry received information related to the study (NCT07613177) titled 'Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)' on May 19.

Brief Summary: The purpose of this multicenter, randomized controlled trial (ULTRASVENT-2) is to evaluate the effect of different positive end-expiratory pressure (PEEP) levels on postoperative oxygenation and lung aeration in adult patients undergoing elective non-cardiac and non-thoracic surgery under general anesthesia. Moving away from traditional binary outcomes, this study utilizes a continuous functional metric, the non-invasive oxygenation index SpO2/FiO2 (S/F ratio), as the primary endpoint to precisely capture the degree of respiratory f...