Clinical Trial: Nortriptyline and the Risk of Serious Adverse Events

U.S., April 15 -- ClinicalTrials.gov registry received information related to the study (NCT07527481) titled 'Nortriptyline and the Risk of Serious Adverse Events' on April 07.

Brief Summary: This is a population-based retrospective, new-user, active comparator cohort study assessing whether initiating a new outpatient prescription of high-dose nortriptyline (>10-150 mg/day), compared with low dose (10 mg/day), is associated with an increased 30-day risk of serious adverse events among older adults with low kidney function (estimated glomerular filtration rate [eGFR] 10-150 mg/day. For the primary comparison, oral nortriptyline at 10 mg/day will serve as the referent group to reduce confounding by indication.

Recruitment Status: COMPLETED...